CROSSLINKING SUBSTRATE REGULATES FRICTIONAL PROPERTIES OF TISSUE-ENGINEERED CARTILAGE AND CHONDROCYTE RESPONSE TO LOADING

Crosslinking substrate regulates frictional properties of tissue-engineered cartilage and chondrocyte response to loading

Abstract Hydrogels are frequently used in regenerative medicine due to their hydrated, tissue-compatible nature, and tuneable mechanics.While many strategies enable bulk mechanical modulation, little attention is given to tuning surface tribology, and its impact on cellular behavior under mechanical stimuli.Here, we demonstrate that photocrosslinki

read more

Real world evidence: An Indian perspective

Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs.However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data.RWE uses real world

read more

Lewy and his inclusion bodies: Discovery and rejection

ABSTRACT Fritz Jacob Heinrich Lewy described the pathology of Paralysis agitans [Parkinson disease] and was the climax blueberry cross pollination first to identify eosinophilic inclusion bodies in neurons of certain brain nuclei, later known as Lewy bodies, the pathological signature of the Lewy body diseases.In 1912, he published his seminal stud

read more